Study of Her2/Neu Expression in Colon Adenocarcinoma and Its Correlation with Clinicopathological Variables
نویسندگان
چکیده
ObjectiveColon cancer is a prevalent human malignancy. HER2/neu is an important oncogene in breast cancer, but its prevalence and significance in colon cancer have been poorly documented. The aim of this study is to determine the rate and pattern of HER2/neu expression in colon carcinoma by immunohistochemistry (IHC). Materials and Methodstwenty-nine colon carcinoma specimens were chosen. IHC for HER2/neu was Performed. Clinicopathologic data and IHC results were analysed. ResultsMost of the carcinoma cases was well differentiated and located in the left side. There was positive HER2/neu staining in a high percent of cases (7 Cases, 24.14%) with both cytoplasmic (5 cases, 17.24%) and membranous (2 cases, 6.90%) staining. There was positive HER2 staining in 28.57% of Stage II, in 57.14% of stage III and 14.28% of stage IV cases. There was positive HER2 staining in 3 (42.35%) of well differentiated and in 4 (57.14%) of moderately differentiated cases. There was no correlation between HER2/neu expression and age, sex, site and type of tumor. Conclusion -The rate of HER2/neu expression in colon carcinoma is high. Because of more prominent membranous staining in higher stages and grades, Herceptin therapy could be helpful in patients with lymph node or distant metastases.
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